Sehgal, M. S. B.; Gondal, I. and Dooley, L.
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|DOI (Digital Object Identifier) Link:||http://doi.org/10.1109/ICASSP.2005.1416319|
|Google Scholar:||Look up in Google Scholar|
Genetic microarray expression data often contains multiple missing values that can significantly affect the performance of statistical and machine learning algorithms. This paper presents an innovative missing value estimation technique, called collateral missing value estimation (CMVE) which has demonstrated superior estimation performance compared with the K-nearest neighbour (KNN) imputation algorithm, the least square impute (LSImpute) and Bayesian principal component analysis (BPCA) techniques. Experimental results confirm that CMVE provides an improvement of 89%, 12% and 10% for the BRCA1, BRCA2 and sporadic ovarian cancer mutations, respectively, compared to the average error rate of KNN, LSImpute and BPCA imputation methods, over a range of randomly selected missing values. The underlying theory behind CMVE also means that it is not restricted to bioinformatics data, but can be successfully applied to any correlated data set.
|Item Type:||Conference Item|
|Academic Unit/Department:||Faculty of Science, Technology, Engineering and Mathematics (STEM) > Computing and Communications
Faculty of Science, Technology, Engineering and Mathematics (STEM)
|Interdisciplinary Research Centre:||Centre for Research in Computing (CRC)|
|Depositing User:||Laurence Dooley|
|Date Deposited:||20 Aug 2008 10:16|
|Last Modified:||02 Aug 2016 17:43|
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