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A collateral missing value estimation algorithm for DNA microarrays

Sehgal, M. S. B.; Gondal, I. and Dooley, L. (2005). A collateral missing value estimation algorithm for DNA microarrays. In: IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP '05), 18-23 March 2005, Philadelphia.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1109/ICASSP.2005.1416319
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Abstract

Genetic microarray expression data often contains multiple missing values that can significantly affect the performance of statistical and machine learning algorithms. This paper presents an innovative missing value estimation technique, called collateral missing value estimation (CMVE) which has demonstrated superior estimation performance compared with the K-nearest neighbour (KNN) imputation algorithm, the least square impute (LSImpute) and Bayesian principal component analysis (BPCA) techniques. Experimental results confirm that CMVE provides an improvement of 89%, 12% and 10% for the BRCA1, BRCA2 and sporadic ovarian cancer mutations, respectively, compared to the average error rate of KNN, LSImpute and BPCA imputation methods, over a range of randomly selected missing values. The underlying theory behind CMVE also means that it is not restricted to bioinformatics data, but can be successfully applied to any correlated data set.

Item Type: Conference Item
ISSN: 1520-6149
Academic Unit/Department: Mathematics, Computing and Technology > Computing & Communications
Interdisciplinary Research Centre: Centre for Research in Computing (CRC)
Item ID: 11427
Depositing User: Laurence Dooley
Date Deposited: 20 Aug 2008 10:16
Last Modified: 21 Jan 2011 14:49
URI: http://oro.open.ac.uk/id/eprint/11427
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