The Open UniversitySkip to content
 

X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy

Ptasińska, Sylwia; Stypczynska, Agnieszka; Nixon, Tony; Mason, Nigel; Klyachko, DV and Sanche, L (2008). X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy. Journal of Chemical Physics, 129(6) pp. 129–134.

Full text available as:
[img]
Preview
PDF (Not Set) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (426Kb)
DOI (Digital Object Identifier) Link: http://doi.org/10.1063/1.2961027
Google Scholar: Look up in Google Scholar

Abstract

In this work, the chemical changes in calf thymus DNA samples were analyzed by X-ray photoelectron spectroscopy XPS. The DNA samples were irradiated for over 5 h and spectra were taken repeatedly every 30 min. In this approach the X-ray beam both damages and probes the samples. In most cases, XPS spectra have complex shapes due to contributions of C, N, and O atoms bonded at several different sites. We show that from a comparative analysis of the modification in XPS line shapes of the C 1s, O 1s, N 1s, and P 2p peaks, one can gain insight into a number of
reaction pathways leading to radiation damage to DNA.

Item Type: Journal Article
Copyright Holders: 2008 American Institute of Physics
Academic Unit/Department: Science > Physical Sciences
Science
Mathematics, Computing and Technology > Engineering & Innovation
Mathematics, Computing and Technology
Interdisciplinary Research Centre: Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Item ID: 11389
Depositing User: Astrid Peterkin
Date Deposited: 18 Aug 2008 12:46
Last Modified: 23 Feb 2016 21:42
URI: http://oro.open.ac.uk/id/eprint/11389
Share this page:

Altmetrics

Scopus Citations

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

▼ Automated document suggestions from open access sources

Actions (login may be required)

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk