Sehgal, M. Shoaib; Gondal, Iqbal; Dooley, Laurence S. and Coppel, Ross
PDF (Not Set)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
|DOI (Digital Object Identifier) Link:||https://doi.org/10.1007/978-3-540-88436-1|
|Google Scholar:||Look up in Google Scholar|
Microarrays are able to measure the patterns of expression of thousands of genes in a genome to give profiles that facilitate much faster analysis of biological processes for diagnosis, prognosis and tailored drug discovery. Microarrays, however, commonly have missing values which can result in erroneous downstream analysis. To impute these missing values, various algorithms have been proposed including Collateral Missing Value Estimation (CMVE), Bayesian Principal Component Analysis (BPCA), Least Square Impute (LSImpute), Local Least Square Impute (LLSImpute) and K-Nearest Neighbour (KNN). Most of these imputation algorithms exploit either the global or local correlation structure of the data, which normally leads to larger estimation errors. This paper presents an enhanced Heuristic Non Parametric Collateral Missing Value Imputation (HCMVI) algorithm which uses CMVE as its core estimator and Heuristic Non Parametric strategy to compute optimal number of estimator genes to exploit optimally both local and global correlations.
|Item Type:||Book Chapter|
|Academic Unit/Department:||Faculty of Science, Technology, Engineering and Mathematics (STEM) > Computing and Communications
Faculty of Science, Technology, Engineering and Mathematics (STEM)
|Interdisciplinary Research Centre:||Centre for Research in Computing (CRC)|
|Depositing User:||Laurence Dooley|
|Date Deposited:||01 Jul 2008|
|Last Modified:||05 Oct 2016 03:46|
|Share this page:|
Download history for this item
These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.